Neutron time-of-flight measurements at the Rensselaer linac

Neutron transmission measurements of Ho, Er, Tm and Au samples have been made from thermal to several hundred eV and the data have been fitted with the SAMMY program. A 16-section NaI multiplicity detector has been used to measure simultaneously capture and scattering partial cross sections. These measurements are used to obtain accurate resonance parameters over this energy range for samples of Mo, Ho, Er, Tm and Au

Block-Transitive Designs in Affine Spaces

This paper deals with block-transitive $t$-$(v,k,\lambda)$ designs in affine spaces for large $t$, with a focus on the important index $\lambda=1$ case. We prove that there are no non-trivial 5-$(v,k,1)$ designs admitting a block-transitive group of automorphisms that is of affine type. Moreover, we show that the corresponding non-existence result holds for 4-$(v,k,1)$ designs, except possibly when the group is one-dimensional affine. Our approach involves a consideration of the finite 2-homogeneous affine permutation groups.Comment: 10 pages; to appear in: "Designs, Codes and Cryptography

Spinons and parafermions in fermion cosets

We introduce a set of gauge invariant fermion fields in fermionic coset models and show that they play a very central role in the description of several Conformal Field Theories (CFT's). In particular we discuss the explicit realization of primaries and their OPE in unitary minimal models, parafermion fields in $Z_k$ CFT's and that of spinon fields in $SU(N)_k, k=1$ Wess-Zumino-Witten models (WZW) theories. The higher level case ($k>1$) will be briefly discussed. Possible applications to QHE systems and spin-ladder systems are addressed.Comment: 6 pages, Latex file. Invited talk at International Seminar dedicated to the memory of D.V.Volkov, Kharkov, January 5-7, 199

CVID-Associated B Cell Activating Factor Receptor Variants Change Receptor Oligomerization, Ligand Binding, and Signaling Responses.

Binding of the B cell activating factor (BAFF) to its receptor (BAFFR) activates in mature B cells many essential pro-survival functions. Null mutations in the BAFFR gene result in complete BAFFR deficiency and cause a block in B cell development at the transition from immature to mature B cells leading therefore to B lymphopenia and hypogammaglobulinemia. In addition to complete BAFFR deficiency, single nucleotide variants encoding BAFFR missense mutations were found in patients suffering from common variable immunodeficiency (CVID), autoimmunity, or B cell lymphomas. As it remained unclear to which extent such variants disturb the activity of BAFFR, we performed genetic association studies and developed a cellular system that allows the unbiased analysis of BAFFR variants regarding oligomerization, signaling, and ectodomain shedding. In addition to genetic association studies, the BAFFR variants P21R, A52T, G64V, DUP92-95, P146S, and H159Y were expressed by lentiviral gene transfer in DG-75 Burkitt's lymphoma cells and analyzed for their impacts on BAFFR function. Binding of BAFF to BAFFR was affected by P21R and A52T. Spontaneous oligomerization of BAFFR was disturbed by P21R, A52T, G64V, and P146S. BAFF-dependent activation of NF-κB2 was reduced by P21R and P146S, while interactions between BAFFR and the B cell antigen receptor component CD79B and AKT phosphorylation were impaired by P21R, A52T, G64V, and DUP92-95. P21R, G64V, and DUP92-95 interfered with phosphorylation of ERK1/2, while BAFF-induced shedding of the BAFFR ectodomain was only impaired by P21R. Although all variants change BAFFR function and have the potential to contribute as modifiers to the development of primary antibody deficiencies, autoimmunity, and lymphoma, P21R is the only variant that was found to correlate positively with CVID

BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors.

Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory B cells seem to survive without BAFF. Here, we show that BAFF activates PI3K/AKT only in naive B cells and changes the expression of genes regulating migration, proliferation, growth, and survival. BAFF-induced PI3K/AKT activation requires direct interactions between BAFFR and the B cell antigen receptor (BCR) components CD79A and CD79B and is enhanced by the AKT coactivator TCL1A. Compared to memory B cells, naive B cells express more surface BCRs, which interact better with BAFFR than IgG or IgA, thus allowing stronger responses to BAFF. As ablation of BAFFR in naive and memory B cells causes cell death independent of BAFF-induced signaling, BAFFR seems to act also as an intrinsic factor for B cell survival

First Measurement of Proton-Proton Elastic Scattering at RHIC

The first result of the pp2pp experiment at RHIC on elastic scattering of polarized protons at sqrt{s} = 200 GeV is reported here. The exponential slope parameter b of the diffractive peak of the elastic cross section in the t range 0.010 <= |t| <= 0.019 (GeV/c)^2 was measured to be b = 16.3 +- 1.6 (stat.) +- 0.9 (syst.) (GeV/c)^{-2} .Comment: 9 pages 5 figure

Steiner t-designs for large t

One of the most central and long-standing open questions in combinatorial design theory concerns the existence of Steiner t-designs for large values of t. Although in his classical 1987 paper, L. Teirlinck has shown that non-trivial t-designs exist for all values of t, no non-trivial Steiner t-design with t > 5 has been constructed until now. Understandingly, the case t = 6 has received considerable attention. There has been recent progress concerning the existence of highly symmetric Steiner 6-designs: It is shown in [M. Huber, J. Algebr. Comb. 26 (2007), pp. 453-476] that no non-trivial flag-transitive Steiner 6-design can exist. In this paper, we announce that essentially also no block-transitive Steiner 6-design can exist.Comment: 9 pages; to appear in: Mathematical Methods in Computer Science 2008, ed. by J.Calmet, W.Geiselmann, J.Mueller-Quade, Springer Lecture Notes in Computer Scienc

Charge Deficiency, Charge Transport and Comparison of Dimensions

We study the relative index of two orthogonal infinite dimensional projections which, in the finite dimensional case, is the difference in their dimensions. We relate the relative index to the Fredholm index of appropriate operators, discuss its basic properties, and obtain various formulas for it. We apply the relative index to counting the change in the number of electrons below the Fermi energy of certain quantum systems and interpret it as the charge deficiency. We study the relation of the charge deficiency with the notion of adiabatic charge transport that arises from the consideration of the adiabatic curvature. It is shown that, under a certain covariance, (homogeneity), condition the two are related. The relative index is related to Bellissard's theory of the Integer Hall effect. For Landau Hamiltonians the relative index is computed explicitly for all Landau levels.Comment: 23 pages, no figure

Klimaatateliers voor Klimaatbestendige Ruimtelijke Inrichting

In verschillende sessies is in kaart gebracht waar in de toekomst knelpunten kunnen optreden en hoe deze mogelijk kunnen worden omgezet in kansen. De aanwezige Gelderse regio’s waren: Stadsregio Arnhem-Nijmegen, Veluwe Vallei, Regio Stedendriehoek en regio de Achterhoek

Multiple Interactions and the Structure of Beam Remnants

Recent experimental data have established some of the basic features of multiple interactions in hadron-hadron collisions. The emphasis is therefore now shifting, to one of exploring more detailed aspects. Starting from a brief review of the current situation, a next-generation model is developed, wherein a detailed account is given of correlated flavour, colour, longitudinal and transverse momentum distributions, encompassing both the partons initiating perturbative interactions and the partons left in the beam remnants. Some of the main features are illustrated for the Tevatron and the LHC.Comment: 69pp, 33 figure